Is It Wrong to Try to Pick Up Girls in a Dungeon? Is It Wrong to Try to Find a Hot Spring in Orario?

Takuma Hirose, an emotionally wounded boy becomes blind after his mother died in his childhood. For medical treatment, he moves to his mother’s home village where he enters a new school.

Arisu, Karube, and Segawa, a trio of highschool delinquents, are bored with their current lives. During a firework celebration, Arisu wishes that he could live in a different world which would be more exciting for him. As such, his wish was granted, and the three were transported into a seemingly post-apocalyptic-like parallel world. After stepping into what seems to be an empty festival, they are greeted by a woman who tells them that they have already "entered their game". After clearing the game, she reveals to them that, in Borderlands, they must play games to survive.

In a world, where the deities have descended from the heavens lies the town of Orario that features the Dungeon, which contains an assortment of monsters from goblins to dragons. Adventurers slay those monsters and take their shards, which are then used to craft magic items. To become an adventurer, people join groups called Familia. Each of which is named after and serves a resident deity. The adventurers and their attributes and abilities are ranked by level, improved by experience and supervised by their Familia's deity. Bell Cranel, a novice adventurer, is the sole member of the Familia under the goddess Hestia. After being saved by top level adventurer Ais Wallenstein of the Loki Familia, he falls in love with her and decides to improve and become worthy of her attention. All the while mostly unaware that other girls, deities and mortals, also develop feelings for him. Especially Hestia herself.